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poly i c  (InvivoGen)


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    InvivoGen poly i c
    Poly I C, supplied by InvivoGen, used in various techniques. Bioz Stars score: 99/100, based on 3906 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/poly+i+c/Pam3CSK4/pm42248850-288-0-14
    Average 99 stars, based on 3906 article reviews
    poly i c - by Bioz Stars, 2026-09
    99/100 stars

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    Related Articles

    other:

    Article Title: A dual-pronged host-directed therapeutic targeting cyclophilin A and pathogenic interferon response abrogates virus-triggered pregnancy pathologies.
    Article Snippet: hTSCs were seeded on 2.5 mg/mL Collagen IV-coated dishes and exposed to poly(I:C) (20 ng) (InvivoGen, #tlrlpic) or ZIKV (MOI = 0.1) in the presence or absence of 2 μM CsA (MedChemExpress, #HY-B0579) for 24 h in maintenance medium.

    Transfection:

    Article Title: DHX36 is a regulatory switch in the interferon-mediated antiviral response
    Article Snippet: .. Poly(I:C) treatments were performed using poly(I:C) (1 μg ml −1 ; InvivoGen; tlrl-pic) delivered by transfection with Lipofectamine 2000 (Thermo Fisher Scientific) according to the manufacturer’s protocol. ..

    Mouse Assay:

    Article Title: A Novel Two-Hit Murine Model of Viral Primed Sepsis-Associated Acute Kidney Injury.
    Article Snippet: Wildtype 8-week-old C57Bl/6J male mice (Jackson Labs, Bar Harbor, ME) were used for the 83 primary data in this study. .. Mice were viral primed with 2.5 mg/kg poly(I:C) (Invivogen, tlrl-pic) or 0.9% 84 saline vehicle via intraperitoneal (IP) injection at timepoint -24 hours (Fig. 1A). .. At 0 hours, mice were 85 challenged either with low dose LPS (Cat. No. L2630, Sigma-Aldrich) at 0.5 mg/kg or sterile 1X phosphate 86 buffered saline (PBS) vehicle via IP injection.

    Saline:

    Article Title: A Novel Two-Hit Murine Model of Viral Primed Sepsis-Associated Acute Kidney Injury.
    Article Snippet: Wildtype 8-week-old C57Bl/6J male mice (Jackson Labs, Bar Harbor, ME) were used for the 83 primary data in this study. .. Mice were viral primed with 2.5 mg/kg poly(I:C) (Invivogen, tlrl-pic) or 0.9% 84 saline vehicle via intraperitoneal (IP) injection at timepoint -24 hours (Fig. 1A). .. At 0 hours, mice were 85 challenged either with low dose LPS (Cat. No. L2630, Sigma-Aldrich) at 0.5 mg/kg or sterile 1X phosphate 86 buffered saline (PBS) vehicle via IP injection.

    Injection:

    Article Title: A Novel Two-Hit Murine Model of Viral Primed Sepsis-Associated Acute Kidney Injury.
    Article Snippet: Wildtype 8-week-old C57Bl/6J male mice (Jackson Labs, Bar Harbor, ME) were used for the 83 primary data in this study. .. Mice were viral primed with 2.5 mg/kg poly(I:C) (Invivogen, tlrl-pic) or 0.9% 84 saline vehicle via intraperitoneal (IP) injection at timepoint -24 hours (Fig. 1A). .. At 0 hours, mice were 85 challenged either with low dose LPS (Cat. No. L2630, Sigma-Aldrich) at 0.5 mg/kg or sterile 1X phosphate 86 buffered saline (PBS) vehicle via IP injection.



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    pUS2 suppresses IFN-β production in DEF cells. A. DEF cells were co-transfected with the IFN-β luciferase reporter plasmid, Renilla luciferase control plasmid, and either pUS2 expression plasmid or empty vector. Cells were stimulated with <t>poly(I:C),</t> and IFN-β promoter activity was measured using a dual-luciferase reporter assay. pUL45, a DPV viral protein, was used as a negative control. B. DEF cells were co-transfected as described above and stimulated with poly(dA:dT). IFN-β promoter activity was measured. C. The mRNA expression levels of IFN-β, OASL, and Mx in DEF cells following poly(I:C) stimulation in the presence or absence of pUS2 were determined by RT-qPCR. D. Expression of pUS2 protein was confirmed by Western blotting analysis.
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    pUS2 suppresses IFN-β production in DEF cells. A. DEF cells were co-transfected with the IFN-β luciferase reporter plasmid, Renilla luciferase control plasmid, and either pUS2 expression plasmid or empty vector. Cells were stimulated with <t>poly(I:C),</t> and IFN-β promoter activity was measured using a dual-luciferase reporter assay. pUL45, a DPV viral protein, was used as a negative control. B. DEF cells were co-transfected as described above and stimulated with poly(dA:dT). IFN-β promoter activity was measured. C. The mRNA expression levels of IFN-β, OASL, and Mx in DEF cells following poly(I:C) stimulation in the presence or absence of pUS2 were determined by RT-qPCR. D. Expression of pUS2 protein was confirmed by Western blotting analysis.
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    pUS2 suppresses IFN-β production in DEF cells. A. DEF cells were co-transfected with the IFN-β luciferase reporter plasmid, Renilla luciferase control plasmid, and either pUS2 expression plasmid or empty vector. Cells were stimulated with <t>poly(I:C),</t> and IFN-β promoter activity was measured using a dual-luciferase reporter assay. pUL45, a DPV viral protein, was used as a negative control. B. DEF cells were co-transfected as described above and stimulated with poly(dA:dT). IFN-β promoter activity was measured. C. The mRNA expression levels of IFN-β, OASL, and Mx in DEF cells following poly(I:C) stimulation in the presence or absence of pUS2 were determined by RT-qPCR. D. Expression of pUS2 protein was confirmed by Western blotting analysis.
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    pUS2 suppresses IFN-β production in DEF cells. A. DEF cells were co-transfected with the IFN-β luciferase reporter plasmid, Renilla luciferase control plasmid, and either pUS2 expression plasmid or empty vector. Cells were stimulated with poly(I:C), and IFN-β promoter activity was measured using a dual-luciferase reporter assay. pUL45, a DPV viral protein, was used as a negative control. B. DEF cells were co-transfected as described above and stimulated with poly(dA:dT). IFN-β promoter activity was measured. C. The mRNA expression levels of IFN-β, OASL, and Mx in DEF cells following poly(I:C) stimulation in the presence or absence of pUS2 were determined by RT-qPCR. D. Expression of pUS2 protein was confirmed by Western blotting analysis.

    Journal: Poultry Science

    Article Title: Duck plague virus US2 promotes p62-mediated autophagic degradation of RIG-I to suppress antiviral signaling

    doi: 10.1016/j.psj.2026.107155

    Figure Lengend Snippet: pUS2 suppresses IFN-β production in DEF cells. A. DEF cells were co-transfected with the IFN-β luciferase reporter plasmid, Renilla luciferase control plasmid, and either pUS2 expression plasmid or empty vector. Cells were stimulated with poly(I:C), and IFN-β promoter activity was measured using a dual-luciferase reporter assay. pUL45, a DPV viral protein, was used as a negative control. B. DEF cells were co-transfected as described above and stimulated with poly(dA:dT). IFN-β promoter activity was measured. C. The mRNA expression levels of IFN-β, OASL, and Mx in DEF cells following poly(I:C) stimulation in the presence or absence of pUS2 were determined by RT-qPCR. D. Expression of pUS2 protein was confirmed by Western blotting analysis.

    Article Snippet: Cells were stimulated with poly(I:C) (MCE, Shanghai, China; Cat# HY-107202) or poly(dA:dT) (Sigma-Aldrich, St. Louis, MO, USA; Cat# P9764) and simultaneously transfected with either the empty vector or the US2 expression plasmid.

    Techniques: Transfection, Luciferase, Plasmid Preparation, Control, Expressing, Activity Assay, Reporter Assay, Negative Control, Quantitative RT-PCR, Western Blot